Antibodies to SARS-CoV-2 remain stable or even increase 7 months post-infection

The levels of IgG antibodies against SARS-CoV-2 Spike protein remain stable, or even increase, 7 months post-infection, according to a follow-up study in a cohort of healthcare workers coordinated by the Barcelona Institute for Global Health (ISGlobal) in collaboration with the Hospital Clinic of Barcelona. 

The results, published in Nature Communications, also support the idea that pre-existing antibodies against common cold (non-pandemic) coronaviruses could protect against COVID-19.

In order to predict the pandemic’s evolution and develop effective strategies, it is critical to better understand the dynamics and duration of immunity to SARS-CoV-2 and the “possible immunity” to SARS-CoV-2 from the antibodies against the coronaviruses that cause common colds. 

With this goal in mind, the team led by ISGlobal researcher Carlota Dobaño followed a cohort of healthcare workers at the Hospital Clinic (SEROCOV study) from the beginning of the pandemic, in order to evaluate the levels of antibodies against different SARS-CoV-2 antigens over time. “This is the first study that evaluates antibodies to such a large panel of SARS-CoV-2 antibodies over 7 months,” says Dobaño. 

The research team analyzed blood samples from 578 participants, taken at four different time points between March and October 2020. They used the Luminex technology to measure, in the same sample, the level and type of IgA, IgM or IgG antibodies to 6 different SARS-CoV-2 antigens as well as the presence of antibodies against the four coronaviruses that cause common colds in humans. 

They also analyzed the neutralizing activity of antibodies in collaboration with researchers at the University of Barcelona. 

The results show that the majority of infections among healthcare workers occurred during the first pandemic wave (the percentage of participants with SARS-CoV-2 antibodies increased only slightly between March and October – from 13.5% to 16.4%). 

With the exception of IgM and IgG antibodies against the nucleocapsid (N), the rest of IgG antibodies (including those with neutralizing activity) remained stable over time, confirming results from other recent studies. Antibodies – including IgM, IgG, and IgA – against the Spike protein can be detected within 1-3 weeks after infection. IgM and IgG antibodies can appear nearly simultaneously but IgM (and IgA) antibodies decay more rapidly than IgG.

“Rather surprisingly, we even saw an increase of IgG anti-Spike antibodies in 75% of the participants from month five onwards, without any evidence of re-exposure to the virus,” says Gemma Moncunill, senior co-author of the study. No reinfections were observed in the cohort. 

Regarding antibodies against human cold coronaviruses (HCoV), the results suggest that they could confer cross-protection against COVID-19 infection or disease. 


Dr. Melvin Sanicas (@Vaccinologist) is a physician-scientist specializing in vaccines, infectious diseases, and global health. 

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